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Cobalt(III)‐Catalyzed [4+2] Annulation of Heterobicyclic Alkenes by sp 2 C−H Activation
Author(s) -
Dey Arnab,
Rathi Anuja,
Volla Chandra M. R.
Publication year - 2018
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201800251
Subject(s) - chemistry , annulation , aromatization , cobalt , catalysis , ring (chemistry) , functional group , medicinal chemistry , stereochemistry , combinatorial chemistry , organic chemistry , polymer
An efficient and convenient cobalt(III)‐catalyzed highly diastereoselective strategy was demonstrated for the synthesis of epoxybenzophenanthridinone derivatives. The sp 2 C−H activation of N ‐methoxybenzamides and their annulation reaction with 7‐oxa/aza benzonorbornadienes proceeds under mild conditions and exhibits excellent functional group tolerance. In addition, the products were transformed to biologically relevant phenanthridinones by an acid‐catalyzed ring opening/aromatization sequence.