Cobalt(III)‐Catalyzed [4+2] Annulation of Heterobicyclic Alkenes by  sp   2   C−H Activation | Zendy

Dey Arnab | Zendy; Rathi Anuja | Zendy; Volla Chandra M. R. | Zendy

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Cobalt(III)‐Catalyzed [4+2] Annulation of Heterobicyclic Alkenes by sp 2 C−H Activation

Author(s) -

Dey Arnab,

Rathi Anuja,

Volla Chandra M. R.

Publication year - 2018

Publication title -

asian journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.846

H-Index - 44

eISSN - 2193-5815

pISSN - 2193-5807

DOI - 10.1002/ajoc.201800251

Subject(s) - chemistry , annulation , aromatization , cobalt , catalysis , ring (chemistry) , functional group , medicinal chemistry , stereochemistry , combinatorial chemistry , organic chemistry , polymer

An efficient and convenient cobalt(III)‐catalyzed highly diastereoselective strategy was demonstrated for the synthesis of epoxybenzophenanthridinone derivatives. The sp 2 C−H activation of N ‐methoxybenzamides and their annulation reaction with 7‐oxa/aza benzonorbornadienes proceeds under mild conditions and exhibits excellent functional group tolerance. In addition, the products were transformed to biologically relevant phenanthridinones by an acid‐catalyzed ring opening/aromatization sequence.

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