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Ruthenium‐Catalyzed Intramolecular Hydroarylation of Arenes with Olefins in Water
Author(s) -
Mukherjee Kallol,
Ramesh E.,
Ghosh Koushik,
Sahoo Akhila K.
Publication year - 2018
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201800241
Subject(s) - chemistry , intramolecular force , ruthenium , amide , catalysis , aqueous medium , combinatorial chemistry , deuterium , reactivity (psychology) , stereochemistry , aqueous solution , organic chemistry , medicinal chemistry , medicine , physics , alternative medicine , pathology , quantum mechanics
A Ru‐catalyzed intramolecular hydroarylation of arenes in an aqueous medium is presented herein. With the aid of methyl phenyl sulfoximine or an amide directing group, this atom‐efficient hydroarylation of arenes ensued dihydrobenzofuran derivatives. Sequential double hydroarylation of arene motifs resulted in highly peripheral‐decorated heterocycles. Deuterium labeling studies and control experiments offer valuable information in understanding the reactivity and the mechanistic data.