Rhodium‐Catalyzed  peri ‐Selective Direct Alkenylation of 1‐(Methylthio)naphthalene | Zendy

Shigeno Masanori | Zendy; Nishii Yuji | Zendy; Satoh Tetsuya | Zendy; Miura Masahiro | Zendy

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Rhodium‐Catalyzed peri ‐Selective Direct Alkenylation of 1‐(Methylthio)naphthalene

Author(s) -

Shigeno Masanori,

Nishii Yuji,

Satoh Tetsuya,

Miura Masahiro

Publication year - 2018

Publication title -

asian journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.846

H-Index - 44

eISSN - 2193-5815

pISSN - 2193-5807

DOI - 10.1002/ajoc.201800212

Subject(s) - chemistry , naphthalene , rhodium , thioether , catalysis , ring (chemistry) , medicinal chemistry , organic chemistry , combinatorial chemistry

A rhodium‐catalyzed direct alkenylation of 1‐(methylthio)naphthalene has been developed using a thioether directing group. The reaction proceeds selectively at the peri ‐position of the naphthalene ring with no competing ortho C−H activation. Both alkynes and alkenes can be used as the coupling counterparts. The alkenylated products with alkynes can be converted to benzo[ de ]thiochromenes by an iodine mediated cyclization method.

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