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Cobalt‐Catalyzed C(sp 3 )−H Functionalization Reactions
Author(s) -
Yoshino Tatsuhiko,
Matsunaga Shigeki
Publication year - 2018
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201800195
Subject(s) - surface modification , chemistry , catalysis , cobalt , reactivity (psychology) , organometallic chemistry , combinatorial chemistry , transition metal , organic chemistry , medicine , alternative medicine , pathology
C−H functionalization reactions hold great potential for the streamlined synthesis of complex molecules and are currently a “hot” topic in organic synthesis. Among the various transition metals that have been used, cobalt has recently attracted increased attention as a catalyst for C−H functionalization reactions, owing to its ready availability and high reactivity. Although a number of cobalt‐catalyzed C(sp 2 )−H functionalization reactions have been reported to date, C(sp 3 )−H functionalization reactions remain challenging. This Focus Review summarizes recent progress in cobalt‐catalyzed C(sp 3 )−H functionalization reactions that involve C−H activation to form organometallic intermediates.