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Rh III ‐Catalyzed C−H Activation: Mizoroki–Heck‐Type Reaction of Maleimides
Author(s) -
Bettadapur Kiran R.,
Sherikar Mahadev Sharanappa,
Lanke Veeranjaneyulu,
Prabhu Kandikere Ramaiah
Publication year - 2018
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201800193
Subject(s) - chemistry , catalysis , heck reaction , medicinal chemistry , ketone , oxidative addition , palladium , organic chemistry
Maleimides are not known to undergo oxidative‐Heck reaction because they lack a syn ‐periplanar β‐hydrogen atom. Herein, we report a C−H activation‐based Mizoroki–Heck‐type reaction of maleimides using ketone as the directing group. The reaction utilizes a Rh III ‐catalyst along with Ag 2 CO 3 as the oxidant to carry out a base‐mediated formal β‐hydride elimination.