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Hydroxoiridium‐Catalyzed sp 3 C−H Alkylation of Indoline Derivatives with Terminal Alkenes
Author(s) -
Nakamura Ikumi,
Yamauchi Daisuke,
Nishimura Takahiro
Publication year - 2018
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201800189
Subject(s) - indoline , chemistry , moiety , alkylation , catalysis , urea , medicinal chemistry , terminal (telecommunication) , organic chemistry , telecommunications , computer science
Direct alkylation of a secondary sp 3 C−H bond of indoline derivatives having a urea moiety with terminal alkenes proceeded in the presence of a hydroxoiridium/1,5‐cyclooctadiene catalyst, which generated an amidoiridium intermediate by reaction with a urea N−H moiety of the indolines, giving the linear addition products in high yields.
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