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Front Cover: Identification of an Ene Reductase from Yeast Kluyveromyces Marxianus and Application in the Asymmetric Synthesis of ( R )‐Profen Esters (Asian J. Org. Chem. 4/2018)
Author(s) -
Li Zhining,
Wang Zexu,
Meng Ge,
Lu Hong,
Huang Zedu,
Chen Fener
Publication year - 2018
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201800188
Subject(s) - chemistry , kluyveromyces marxianus , yeast , ene reaction , front cover , cover (algebra) , stereochemistry , kluyveromyces , biochemistry , saccharomyces cerevisiae , mechanical engineering , engineering
KYE2 , a new ene‐reductase, belonging to the Old Yellow Enzyme family was identified from Kluyveromyces marxianus CBS4857 through genome mining. KYE2 displayed a broad substrate spectrum for the bioreduction of activated alkenes and was further successfully applied in the highly enantioselective syntheses of various ( R )‐profen methyl esters, including ( R )‐flurbiprofen methyl ester as shown in the Front Cover. More information can be found in the Full Paper by Zedu Huang, Fener Chen et al. on page 763 in Issue 4, 2018 (DOI: 10.1002/ajoc.201800059).