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Highly Efficient Construction of 2‐Fluoroalkyl Quinolines through a Palladium‐Catalyzed 6‐ endo ‐trig Heck Cyclization Reaction
Author(s) -
Han Fangwai,
Yang Wenqing,
Zhao Aichun,
Zheng Ruihong,
Ji Chenhui,
Liu Xinqi,
Liu Guiyan,
Chen Chen
Publication year - 2018
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201800187
Subject(s) - chemistry , quinoline , palladium , catalysis , heck reaction , substrate (aquarium) , combinatorial chemistry , selectivity , scope (computer science) , molecule , organic chemistry , oceanography , computer science , programming language , geology
A highly efficient Pd 0 ‐catalyzed 6‐ endo ‐trig Heck cyclization reaction has been developed for the construction of 2‐fluoroalkyl quinolines, which are important structural motifs for bioactive molecules. This process offers broad substrate scope, with excellent 6‐ endo selectivity, and affords quinoline derivatives in moderate‐to‐excellent yields.