Ru II ‐Catalyzed Regioselective Debrominative Annulation Reaction of Salicylaldehydes and Propargyl Bromide: Synthesis of 2‐Methylchromones | Zendy

Borthakur Somadrita | Zendy; Kaishap Partha P. | Zendy; Gogoi Sanjib | Zendy

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Ru II ‐Catalyzed Regioselective Debrominative Annulation Reaction of Salicylaldehydes and Propargyl Bromide: Synthesis of 2‐Methylchromones

Author(s) -

Borthakur Somadrita,

Kaishap Partha P.,

Gogoi Sanjib

Publication year - 2018

Publication title -

asian journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.846

H-Index - 44

eISSN - 2193-5815

pISSN - 2193-5807

DOI - 10.1002/ajoc.201800161

Subject(s) - annulation , chemistry , propargyl , regioselectivity , propargyl bromide , catalysis , bromide , organic chemistry , medicinal chemistry , combinatorial chemistry

A new method for the annulation reaction of salicylaldehydes with propargyl bromide is described. This Ru II ‐catalyzed annulation reaction provides 2‐methylchromones, which are a substructure of many biologically active natural products. The annulation reaction could be further extended to the synthesis of 2‐methylfuran‐fused compounds.

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