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Ru II ‐Catalyzed Regioselective Debrominative Annulation Reaction of Salicylaldehydes and Propargyl Bromide: Synthesis of 2‐Methylchromones
Author(s) -
Borthakur Somadrita,
Kaishap Partha P.,
Gogoi Sanjib
Publication year - 2018
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201800161
Subject(s) - annulation , chemistry , propargyl , regioselectivity , propargyl bromide , catalysis , bromide , organic chemistry , medicinal chemistry , combinatorial chemistry
A new method for the annulation reaction of salicylaldehydes with propargyl bromide is described. This Ru II ‐catalyzed annulation reaction provides 2‐methylchromones, which are a substructure of many biologically active natural products. The annulation reaction could be further extended to the synthesis of 2‐methylfuran‐fused compounds.