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Asymmetric Organocatalytic Electrophilic Heterofunctionalization of Oxindoles
Author(s) -
Freckleton Megan,
Baeza Alejandro,
Benavent Llorenç,
Chinchilla Rafael
Publication year - 2018
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201800146
Subject(s) - chemistry , organocatalysis , electrophile , electrophilic amination , enantioselective synthesis , heteroatom , amination , hydroxylation , halogenation , organic chemistry , oxindole , combinatorial chemistry , catalysis , ring (chemistry) , enzyme
Abstract The asymmetric synthesis of 3‐substituted oxindoles is a topic of considerable importance because these functionalized heterocycles are found in many natural products and drugs. In the last decade, significant advances have been made towards the asymmetric synthesis of 3‐heteroatom‐substituted oxindoles as a result of major improvements in asymmetric organocatalysis. This review will focus on the different types of asymmetric electrophilic organocatalyzed reactions, including the amination, halogenation, hydroxylation, and sulfenylation of oxindoles to form their enantioenriched 3‐heterosubstituted derivatives.