Premium
Copper‐Catalyzed Bis‐ or Trifunctionalization of Alkynyl Carboxylic Acids: An Efficient Route to Bis‐ and Tris‐selenide Alkenes
Author(s) -
Chen Jing,
Su ShiXia,
Hu DaChao,
Cui FeiHu,
Xu YanLi,
Chen YanYan,
Ma XianLi,
Pan YingMing,
Liang Ying
Publication year - 2018
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201800086
Subject(s) - selenide , chemistry , tris , catalysis , copper , medicinal chemistry , toluene , organic chemistry , selenium , biochemistry
A highly efficient copper‐catalyzed protocol for the synthesis of bis‐ and tris‐selenide alkenes from alkynyl carboxylic acids and diselenides has been developed. The reaction of alkynyl carboxylic acids and diselenides in the presence of CuI/Cs 2 CO 3 /toluene under white light LEDs only gave bis‐selenide alkenes, whereas tris‐selenide alkenes were obtained in the presence of a CuI/Cs 2 CO 3 /NMP system. This method provides a rapid access to bis‐ and tris‐selenide alkenes derivatives.