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Enzyme‐Responsive Supramolecular Nanoparticles Based on Carboxyl‐Modified Cyclodextrins for Dual Substrate Loading
Author(s) -
Han Xu,
Chen Yong,
Sun HeLue,
Liu Yu
Publication year - 2018
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201800076
Subject(s) - chemistry , supramolecular chemistry , butyrylcholinesterase , substrate (aquarium) , enzyme , combinatorial chemistry , nanoparticle , drug delivery , molecule , organic chemistry , nanotechnology , acetylcholinesterase , aché , oceanography , materials science , geology
Enzyme‐responsive supramolecular assemblies have recently attracted more and more attention in biomaterial fields because of their controlled drug release at specific sites where the target enzyme is located. In this work, an enzyme‐responsive nanoparticle (NP) was successfully constructed through the molecular‐induced aggregation of hepta‐carboxyl‐modified cyclodextrins (carboxyl‐CDs) towards the enzyme‐responsive small molecule myristoylcholine, and the resulting spherical NP from carboxyl‐CD and myristoylcholine was fully characterized. Significantly, this NP can load two different substrates, that is, amantadine and anionic dye HPTS, and disassemble when treated by butyrylcholinesterase (BChE), an enzyme that can break the ester linkage of myristoylcholine chloride. Therefore, this NP may find applications in dual drug delivery.