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The Chemistry between Hypervalent Iodine(III) Reagents and Organophosphorus Compounds
Author(s) -
Murphy Graham K.,
Racicot Léanne,
Carle Myriam S.
Publication year - 2018
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201800058
Subject(s) - hypervalent molecule , chemistry , reagent , nucleophile , electrophile , aryl , combinatorial chemistry , iodine , organic chemistry , alkyl , catalysis
The intersection between the chemistries of hypervalent iodine (HVI) reagents and organophosphorus compounds holds significant potential. To date, the merging of these research spheres has led to novel iodane motifs, many of which have been used in new oxyphosphorylation methodologies. In addition, HVI reagents have proven easily capable of transferring electrophilic carbon‐based (alkyl, aryl, alkynyl, etc.) ligands to various phosphorus nucleophiles. Furthermore, the ease with which HVI reagents oxidize phosphorus has led to novel esterification, amidation, alcohol functionalization and peptide coupling reactions. This Focus Review summarizes the chemistry to‐date between these two important classes of compounds.