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Bestmann–Ohira Reagent: A Convenient and Promising Reagent in the Chemical World
Author(s) -
Dhameja Manoj,
Pandey Jyoti
Publication year - 2018
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201800051
Subject(s) - reagent , chemistry , synthon , cycloaddition , regioselectivity , organic chemistry , combinatorial chemistry , isoquinoline , enol , organic synthesis , catalysis
The Bestmann–Ohira reagent is a unique and versatile reagent in organic synthesis. It is a well‐known homologating agent for the conversion of aldehydes into the corresponding terminal alkynes. Recently, it has also been used as a potent cycloaddition partner in 1,3‐dipolar cycloaddition reactions. The Bestmann–Ohira reagent can be readily accessed from commercially available sources. It has found tremendous application in the regioselective synthesis of a variety of organic synthons, including alkynes, triazoles, triazolines, pyrazoles, oxazoles, thiazoles, isoquinoline N ‐oxides, indazoles, pyrroles, and enol ethers in good‐to‐very‐good yields.