Facile Intramolecular Cyclization of  N ‐(2‐Hydroxybenzoyl)hydrazones to  N , N′ ‐Diacetyl Benzo‐1,3,4‐oxadiazepine Derivatives | Zendy

Chan Pei Qie | Zendy; Lee Yean Kee | Zendy; Rahman Noorsaadah Abd. | Zendy

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Facile Intramolecular Cyclization of N ‐(2‐Hydroxybenzoyl)hydrazones to N , N′ ‐Diacetyl Benzo‐1,3,4‐oxadiazepine Derivatives

Author(s) -

Chan Pei Qie,

Lee Yean Kee,

Rahman Noorsaadah Abd.

Publication year - 2018

Publication title -

asian journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.846

H-Index - 44

eISSN - 2193-5815

pISSN - 2193-5807

DOI - 10.1002/ajoc.201800014

Subject(s) - chemistry , intramolecular force , substituent , reactivity (psychology) , catalysis , medicinal chemistry , intramolecular reaction , stereochemistry , organic chemistry , medicine , alternative medicine , pathology

A facile synthesis of seven‐membered benzo‐1,3,4‐oxadiazepines through one‐step intramolecular cyclization of N ‐(2‐hydroxybenzoyl)hydrazones has been established. The catalytic and substituent effects on the reactivity of this intramolecular cyclization were investigated. Through this strategy, a series of benzo‐1,3,4‐oxadiazepine derivatives were prepared (with yields up to 83 %).

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