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Nanoceria‐Catalyzed Selective Synthesis of α‐Hydroxy Amides through the Reduction of an Unusual Class of α‐Keto Amides
Author(s) -
Mishra Ashish A.,
Bhanage Bhalchandra M.
Publication year - 2018
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201800007
Subject(s) - catalysis , chemistry , oxalic acid , thermogravimetric analysis , thermal stability , hydrothermal circulation , hydrothermal synthesis , organic chemistry , combinatorial chemistry , nuclear chemistry , chemical engineering , engineering
Herein, we report the preparation of a heterogeneous, efficient, and recyclable ceria nanosphere (NS) catalyst, which was prepared by hydrothermal synthesis with oxalic acid as a capping agent. The morphology and thermal stability of the catalyst were studied by using SEM, XRD, and thermogravimetric analysis (TGA). This nanoceria catalyst was used for the chemoselective hydrogenation of deactivated α‐keto amides by using NaBH 4 . This reaction did not work in the absence of the nanoceria catalyst. A series of substituted hydroxy amides were prepared in very good yields with low catalyst loading.