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Lewis Acid‐Catalyzed Yne‐Carbonyl Metathesis of Ynamides and Cyclobutanones: Facile Synthesis of Functionalized Alkylidenecyclobutanes
Author(s) -
Sun YuLi,
Chen Ling,
Cao Jian,
Sun FengNa,
Xu Zheng,
Zheng ZhanJiang,
Cui YuMing,
Xu LiWen
Publication year - 2018
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201700709
Subject(s) - chemistry , catalysis , metathesis , amide , lewis acids and bases , carbonyl group , imide , organic chemistry , functional group , combinatorial chemistry , atom economy , salt metathesis reaction , stereochemistry , polymer , polymerization
An atom‐economical strategy for the synthesis of functionalized alkylidenecyclobutanes (ACBs) via Lewis acid‐catalyzed yne‐carbonyl metathesis of ynamides and cyclobutanones is described. This strategy features mild reaction conditions, ready availability of starting materials, and broad functional group tolerability. Furthermore, the imide group is easily converted to acid, ester, and amide, thus providing an efficient access to various functionalized ACBs.