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Sustainable and Efficient CuI‐NPs‐Catalyzed Cross‐Coupling Approach for the Synthesis of Tertiary 3‐Aminopropenoates, Triazoles, and Ciprofloxacin
Author(s) -
Nayal Onkar S.,
Thakur Maheshwar S.,
Kumar Manoranjan,
Upadhyay Rahul,
Maurya Sushil K.
Publication year - 2018
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201700682
Subject(s) - chemistry , catalysis , combinatorial chemistry , nanoparticle , iodide , nanotechnology , organic chemistry , materials science
The unique properties of metal nanoparticles have attracted significant attention from synthetic chemists, notably for application in heterogeneous catalysis. Herein, we report a highly efficient, sustainable, and atom‐economical approach for the synthesis of tertiary 3‐aminopropenoates from alkynes and secondary amines by using heterogeneous copper(I) iodide nanoparticles (CuI NPs) as a catalyst. The broad utility of this strategy is demonstrated by the synthesis of a wide range of tertiary 3‐aminopropenoates. The value of this transformation has been highlighted by the synthesis of biologically active ciprofloxacin and its derivatives on a gram scale. This method was also applied to the synthesis of 1,4‐disubstituted 1,2,3‐triazoles.