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Recent Developments and Perspectives in the Asymmetric Mannich Reaction
Author(s) -
Saranya Salim,
Harry Nissy Ann,
Krishnan K. Keerthi,
Anilkumar Gopinathan
Publication year - 2018
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201700679
Subject(s) - chemistry , mannich reaction , organic chemistry , catalysis , organocatalysis , combinatorial chemistry , enantioselective synthesis , computational chemistry
The asymmetric Mannich reaction is a very important method for C−C bond formation, and it is the classical method for the preparation of β‐amino ketones and aldehydes. The resulting β‐amino carbonyl compounds are widely found in nature, which attests to the importance of this reaction. This Focus Review provides an overview of asymmetric Mannich reactions, the various catalysts that have been used, and its applications, for papers published since 2013.