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Palladium‐Catalyzed Direct Oxidative Esterification of Indoles at the C3 Position: A Novel Prospect for C(sp 2 )−H Acyloxylation
Author(s) -
Song Jian,
Cui Jie,
Liang Hanbing,
Liu Qing,
Dong Yunhui,
Liu Hui
Publication year - 2018
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201700663
Subject(s) - chemistry , palladium , catalysis , oxidative phosphorylation , organic chemistry , base (topology) , medicinal chemistry , biochemistry , mathematical analysis , mathematics
An efficient palladium‐catalyzed direct oxidative esterification reaction of indoles with both aliphatic and aromatic carboxylic acids is reported. The use of Ag 2 CO 3 is crucial to this transformation, as it functions as both a base and an oxidant for the regeneration of the palladium(II) catalyst. This methodology represents a novel prospect for C(sp 2 )−H acyloxylation and will promote interest in direct C(sp 2 )−H esterification.