Palladium‐Catalyzed Direct Oxidative Esterification of Indoles at the C3 Position: A Novel Prospect for C(sp 2 )−H Acyloxylation | Zendy

Song Jian | Zendy; Cui Jie | Zendy; Liang Hanbing | Zendy; Liu Qing | Zendy; Dong Yunhui | Zendy; Liu Hui | Zendy

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Palladium‐Catalyzed Direct Oxidative Esterification of Indoles at the C3 Position: A Novel Prospect for C(sp 2 )−H Acyloxylation

Author(s) -

Song Jian,

Cui Jie,

Liang Hanbing,

Liu Qing,

Dong Yunhui,

Liu Hui

Publication year - 2018

Publication title -

asian journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.846

H-Index - 44

eISSN - 2193-5815

pISSN - 2193-5807

DOI - 10.1002/ajoc.201700663

Subject(s) - chemistry , palladium , catalysis , oxidative phosphorylation , organic chemistry , base (topology) , medicinal chemistry , biochemistry , mathematical analysis , mathematics

An efficient palladium‐catalyzed direct oxidative esterification reaction of indoles with both aliphatic and aromatic carboxylic acids is reported. The use of Ag 2 CO 3 is crucial to this transformation, as it functions as both a base and an oxidant for the regeneration of the palladium(II) catalyst. This methodology represents a novel prospect for C(sp 2 )−H acyloxylation and will promote interest in direct C(sp 2 )−H esterification.

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