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TEMPO‐Promoted C(sp 3 )−H Hydroxylation of 2‐Oxindoles at Room Temperature
Author(s) -
Zhu WenMing,
Bao WenHui,
Ying WeiWei,
Chen WeiTing,
Huang YiLing,
Ge GuoPing,
Chen GanPing,
Wei WenTing
Publication year - 2018
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201700660
Subject(s) - chemistry , hydroxylation , reagent , functional group , molecule , combinatorial chemistry , stereochemistry , organic chemistry , enzyme , polymer
3‐Hydroxy‐2‐oxindoles are valuable biologically active molecules, and efficient methods for their synthesis under mild condition are highly sought after. Here we report a base‐ and metal‐free C(sp 3 )−H hydroxylation of 2‐oxindoles promoted by commercially available inexpensive TEMPO and atmospheric air as a hydroxylation reagent at room temperature. This protocol provides a mild and simple strategy for the construction of C−O bonds in moderate to good yields with wide functional group tolerance.