TEMPO‐Promoted C(sp 3 )−H Hydroxylation of 2‐Oxindoles at Room Temperature | Zendy

Zhu WenMing | Zendy; Bao WenHui | Zendy; Ying WeiWei | Zendy; Chen WeiTing | Zendy; Huang YiLing | Zendy; Ge GuoPing | Zendy; Chen GanPing | Zendy; Wei WenTing | Zendy

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TEMPO‐Promoted C(sp 3 )−H Hydroxylation of 2‐Oxindoles at Room Temperature

Author(s) -

Zhu WenMing,

Bao WenHui,

Ying WeiWei,

Chen WeiTing,

Huang YiLing,

Ge GuoPing,

Chen GanPing,

Wei WenTing

Publication year - 2018

Publication title -

asian journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.846

H-Index - 44

eISSN - 2193-5815

pISSN - 2193-5807

DOI - 10.1002/ajoc.201700660

Subject(s) - chemistry , hydroxylation , reagent , functional group , molecule , combinatorial chemistry , stereochemistry , organic chemistry , enzyme , polymer

3‐Hydroxy‐2‐oxindoles are valuable biologically active molecules, and efficient methods for their synthesis under mild condition are highly sought after. Here we report a base‐ and metal‐free C(sp 3 )−H hydroxylation of 2‐oxindoles promoted by commercially available inexpensive TEMPO and atmospheric air as a hydroxylation reagent at room temperature. This protocol provides a mild and simple strategy for the construction of C−O bonds in moderate to good yields with wide functional group tolerance.

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