Premium
Iron‐Catalyzed Intramolecular Reductive Coupling of Unactivated Aldehydes and Arylalkenes with Isopropanol
Author(s) -
Zheng YanLong,
Liu YanYao,
Xu XueTao,
Zhang Kun,
Ye Mengchun
Publication year - 2018
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201700622
Subject(s) - intramolecular force , chemistry , catalysis , coupling (piping) , medicinal chemistry , organic chemistry , combinatorial chemistry , mechanical engineering , engineering
FeCl 3 ‐catalyzed intramolecular reductive coupling of unactivated aldehydes and arylalkenes with isopropanol as a terminal reductant under mild and easy‐to‐handle conditions has been developed. A series of five‐, six‐, seven‐ and eight‐membered carbocyclic alcohols were synthesized in moderate to excellent yields with high regioselectivities.