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Enantioselective Reactions Catalyzed by N‐Heterocyclic Carbenes
Author(s) -
Zhao Ming,
Zhang YuTong,
Chen Jie,
Zhou Ling
Publication year - 2018
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201700538
Subject(s) - enantioselective synthesis , chemistry , organocatalysis , catalysis , nucleophile , carbene , combinatorial chemistry , nucleophilic addition , covalent bond , organic chemistry
Enantioselective organocatalysis by using N‐heterocyclic carbenes (NHCs) has emerged as a powerful strategy for the construction of complex chiral molecules. Recently, remarkable advances have been made in enantioselective NHC‐catalyzed reactions that involve diverse activation intermediates, such as Breslow intermediates, homoenolate intermediates, α,β‐unsaturated acylazoliums, azolium enolates, and azolium dienolates, which are generated by the nucleophilic addition of NHCs to aldehydes. Furthermore, NHC‐catalyzed reactions that proceed through non‐covalent bonding interactions have also been developed.