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Rhodium‐Catalyzed Alkenyl C−H Activation and Oxidative Coupling with Allylic Alcohols
Author(s) -
Yan Rui,
Wang ZhongXia
Publication year - 2018
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201700515
Subject(s) - allylic rearrangement , chemistry , catalysis , allylic alcohol , rhodium , alcohol , oxidative phosphorylation , medicinal chemistry , aryl , alkyl , oxidative coupling of methane , organic chemistry , biochemistry
[Cp*RhCl 2 ] 2 was demonstrated to catalyze the oxidative coupling of alkenylpyridines with allylic alcohols through alkenyl C−H activation in the presence of AgOTf and AgOAc to afford β‐alkenyl ketones and aldehydes in moderate to good yields. Allylic alcohol, 1‐aryl and 1‐alkyl allylic alcohols can be coupled with various alkenylpyridines. The reaction occurred at the γ‐position of allylic alcohols and the cis ‐β‐position of the alkenylpyridines.