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Rhodium(III)‐Catalyzed C−H Activation of O ‐Acetyl Ketoximes/ N ‐Methoxybenzamides toward the Synthesis of Isoquinoline/Isoquinolone‐Fused Bicycles
Author(s) -
Vijayan Ajesh,
Jumaila Choorappulan Ummu,
Radhakrishnan Kokkuvayil Vasu
Publication year - 2017
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201700377
Subject(s) - chemistry , rhodium , isoquinoline , bicyclic molecule , catalysis , medicinal chemistry , stereochemistry , combinatorial chemistry , organic chemistry
An efficient rhodium(III)‐catalyzed C−H activation approach for the construction of fused heterocyclic motifs with urea‐derived bicyclic olefins has been demonstrated. A rhodium‐catalyzed reaction of O ‐acetyl ketoximes with these bicyclic motifs furnished isoquinoline derivatives, whereas isoquinolone‐fused bicyclic olefins were obtained with the reaction of N ‐methoxybenzamides.