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Cover Feature: Advances in Aza‐Claisen‐Rearrangement‐Induced Ring‐Expansion Strategies (Asian J. Org. Chem. 9/2017)
Author(s) -
Jung JongWha,
Kim SeokHo,
Suh YoungGer
Publication year - 2017
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201700354
Subject(s) - chemistry , claisen rearrangement , cover (algebra) , ring (chemistry) , feature (linguistics) , combinatorial chemistry , stereochemistry , organic chemistry , mechanical engineering , linguistics , philosophy , engineering
Ring expansion : Aza‐Claisen rearrangement (ACR)‐induced ring expansion guarantees a highly reliable stereochemical outcome of a [3,3]‐sigmatropic rearrangement. It provides access to useful organic molecules via concomitant ring expansion utilizing nitrogen‐atom‐tethered azacycles of various ring sizes. The ACR‐induced ring expansion strategy complements the conventional synthetic routes for medium‐to‐large azacycles, whose synthesis is often entropically unfavorable. This overview focuses on the recent applications of ACR‐induced ring expansion strategies for the syntheses of bioactive and structurally diverse alkaloids. More information can be found in the Focus Review by Jong‐Wha Jung, Seok‐Ho Kim and Young‐Ger Suh on page 1117 in Issue 9, 2017 (DOI: 10.1002/ajoc.201700202).