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Ligand‐Free Pd/Cu‐Catalyzed Aminosulfonylation of Aryl Iodides for Direct Sulfonamide Syntheses
Author(s) -
Zhu Haibo,
Shen Yajing,
Deng Qinyue,
Le ZhangGao,
Tu Tao
Publication year - 2017
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201700350
Subject(s) - chemistry , catalysis , aryl , ligand (biochemistry) , sulfonamide , combinatorial chemistry , sulfur , substrate (aquarium) , octane , organic chemistry , biochemistry , alkyl , receptor , oceanography , geology
A ligand‐free Pd/Cu‐catalyzed aminosulfonylation of aryl iodides has been successfully developed. The protocol provides a straightforward approach to access a broad range of structurally intriguing sulfonamides in one pot, at low catalyst loading from the sulfur dioxide surrogate 1,4‐diazabicyclo[2.2.2]octane bis(sulfur oxide) (DABSO) and O ‐benzoyl hydroxylamines under mild conditions. Even without additional ligands, the protocol reveals broad substrate scope for both partners and tolerates all kinds of functional groups. Furthermore, the proposed sulfinate intermediate could be critical for this ligand‐free catalytic transformation.