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Para ‐Selective C−H Thioetherification
Author(s) -
Hsu WeiChieh,
Li ChaoEn,
Lee ChinFa
Publication year - 2017
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201700336
Subject(s) - chemistry , regioselectivity , thioether , halogenation , amine gas treating , nitro , trifluoromethyl , pyridine , oxalic acid , medicinal chemistry , catalysis , coupling reaction , organic chemistry , alkyl
We report the synthesis of thioether with high regioselectivity. The reaction proceeds through regioselective bromination followed by a copper/oxalic diamide‐catalyzed C−S bond cross‐coupling reaction. Functional groups, such as fluoro, chloro, trifluoromethyl, nitro, unprotected amine and pyridine, are tolerated by the reaction conditions.