Direct Amination of α‐Hydroxy Amides | Zendy

Chandgude Ajay L. | Zendy; Dömling Alexander | Zendy

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Direct Amination of α‐Hydroxy Amides

Author(s) -

Chandgude Ajay L.,

Dömling Alexander

Publication year - 2017

Publication title -

asian journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.846

H-Index - 44

eISSN - 2193-5815

pISSN - 2193-5807

DOI - 10.1002/ajoc.201700277

Subject(s) - chemistry , amination , amide , primary (astronomy) , indole test , combinatorial chemistry , organic chemistry , reaction conditions , ligand (biochemistry) , base (topology) , catalysis , biochemistry , receptor , mathematical analysis , physics , mathematics , astronomy

A TiCl 4 ‐mediated reaction for the direct amination of α‐hydroxy amides has been developed. This simple, general, additive/base/ligand‐free reaction is mediated by economical TiCl 4 . The reaction runs under mild conditions. This highly efficient C−N bond formation protocol is valid for diverse amines, including primary, secondary and heterocyclic amines, and even a primary amide and indole.

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