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Direct Amination of α‐Hydroxy Amides
Author(s) -
Chandgude Ajay L.,
Dömling Alexander
Publication year - 2017
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201700277
Subject(s) - chemistry , amination , amide , primary (astronomy) , indole test , combinatorial chemistry , organic chemistry , reaction conditions , ligand (biochemistry) , base (topology) , catalysis , biochemistry , receptor , mathematical analysis , physics , mathematics , astronomy
A TiCl 4 ‐mediated reaction for the direct amination of α‐hydroxy amides has been developed. This simple, general, additive/base/ligand‐free reaction is mediated by economical TiCl 4 . The reaction runs under mild conditions. This highly efficient C−N bond formation protocol is valid for diverse amines, including primary, secondary and heterocyclic amines, and even a primary amide and indole.