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Visible‐Light‐Mediated Dehydrogenative Cross‐Coupling: Synthesis of Nonsymmetrical Atropisomeric Biaryls
Author(s) -
Wang Junlei,
Zhao Yating,
Gao Han,
Gao GuoLin,
Yang Chao,
Xia Wujiong
Publication year - 2017
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201700242
Subject(s) - chemistry , aniline , phenol , combinatorial chemistry , coupling (piping) , coupling reaction , helicene , photochemistry , organic chemistry , catalysis , molecule , mechanical engineering , engineering
The direct cross‐dehydrogenative coupling reactions of 2‐naphthylamine/2‐naphthol derivatives with aniline/phenol derivatives for the preparation of nonsymmetrical atropisomeric biaryl compounds, especially BINOL‐type biaryls, using a photocatalyst with irradiation under blue LEDs at room temperature, are described. This protocol provides efficient and simple access to nonsymmetrical atropisomeric biaryls in good yields, which are often found in natural products and are useful for materials chemistry.