Practical Synthesis of Two Different Pseudoenantiomeric Organocatalysts with cis ‐Cyclohexanediamine Structure from a Common Chiral Source

An approach has been developed for the practical synthesis of two different, structurally robust, pseudoenantiomeric amino Tf‐amido organocatalysts with a cis ‐1,2‐cyclohexanediamine structure. These pseudoenantiomeric organocatalysts, which are very useful for the practical synthesis of both enantiomeric aldol products, are easily prepared from commercially available cis ‐4‐cyclohexene‐1,2‐dicarboxylic acid in a four‐step sequence. The Diels–Alder strategy of 2‐alkyl‐1,3‐butadiene and maleic anhydride would provide a general approach to the facile synthesis of various pseudoenantiomeric organocatalysts.