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Chemoenzymatic Synthesis of the HMG‐CoA Reductase Inhibitor Rosuvastatin and Natural Styryl Lactone Cryptomoscatone E1
Author(s) -
Ramesh Perla,
Anjibabu Ramisetti,
Reddy Yarram Narasimha,
Yedukondalu Maddipatla,
Reddy Thatikonda Narendar,
Kummari Bhaskar,
Raju Atla,
Srinivasu Navuluri
Publication year - 2017
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201700228
Subject(s) - chemistry , rosuvastatin , hydrolysis , reductase , lactone , hmg coa reductase , sodium acetate , enzyme , ethyl acetate , phosphate , stereochemistry , organic chemistry , medicinal chemistry , medicine
Racemic syn ‐ethyl ( E )‐2‐(2,2‐dimethyl‐6‐styryl‐1,3‐dioxan‐4‐yl)acetate is hydrolyzed with high enantioselectivity by Novozyme‐435 in 0.05 m sodium phosphate buffer at room temperature. The optically pure unreacted ethyl 2‐((4 R ,6 S )‐2,2‐dimethyl‐6‐(( E )‐styryl)‐1,3‐dioxan‐4‐yl)acetate and hydrolyzed (4 S ,6 R )‐acid are used in the synthesis of HMG‐CoA reductase inhibitor rosuvastatin and the naturally occurring styryl lactone cryptomoscatone E1, respectively.