Premium
Synthesis of Phosphaisoquinolin‐1‐one by Annulation of Aryl Phosphinamides with Allenes through a Cobalt‐Promoted C−H Functionalization
Author(s) -
Yao Xia,
Jin Lu,
Rao Yu
Publication year - 2017
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201700215
Subject(s) - chemistry , annulation , surface modification , cobalt , aryl , reactivity (psychology) , combinatorial chemistry , functional group , transition metal , organic chemistry , catalysis , medicine , alkyl , alternative medicine , polymer , pathology
An efficient and convenient cobalt‐promoted annulation reaction has been established for the synthesis of biologically relevant phosphaisoquinolin‐1‐ones, which represents the first example of a transition‐metal‐promoted C−H/N−H functionalization of aryl phophinamides with allenes. Through this strategy, three different types of novel phosphaisoquinolin‐1‐one derivatives can be readily prepared in good yields. This new strategy exhibited several advantages, including easily accessible starting materials, good functional group tolerance, and excellent reactivity.