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Asymmetric Synthesis of Functionalized Nitrophenols via a Copper(II)‐Mediated Bromination/Debromination Aromatization Sequence
Author(s) -
Liu XueLi,
Zhang XiaoLong,
Guo YanJun,
Meng ChenHong,
Xia AiBao,
Xu DanQian
Publication year - 2017
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201700208
Subject(s) - aromatization , chemistry , halogenation , stereospecificity , copper , sequence (biology) , organic chemistry , medicinal chemistry , catalysis , biochemistry
A stereospecific copper(II)‐mediated bromination/debromination aromatization sequence leading to functionalized nitrophenols from corresponding γ‐nitroketones is described. It provided a simple methodology for the construction of nitrophenols in moderate to good yields and moderate to high enantioselectivities.
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