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Lewis Acid‐Catalyzed Stereoselective [7+7] Intermolecular Cyclization of Aniline‐Tethered Alkylidenecyclopropanes: A One‐Step Synthetic Protocol of 14‐Membered Macrocyclic Dimers
Author(s) -
Hu XuBo,
Chen Kai,
Yang XueYan,
Wei Yin,
Shi Min
Publication year - 2017
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201700190
Subject(s) - chemistry , stereoselectivity , aniline , lewis acids and bases , intermolecular force , catalysis , ring (chemistry) , stereochemistry , medicinal chemistry , organic chemistry , combinatorial chemistry , molecule
A one‐step stereoselective synthetic method of 14‐membered aza‐macrocyclic dimers has been developed by a Lewis acid‐catalyzed ring‐opening and intermolecular cyclization reaction of aniline‐tethered alkylidenecyclopropanes, affording 14‐membered aza‐macrocyclic dimers (mainly as E ‐configuration) in moderate to good yields under mild conditions.