Lewis Acid‐Catalyzed Stereoselective [7+7] Intermolecular Cyclization of Aniline‐Tethered Alkylidenecyclopropanes: A One‐Step Synthetic Protocol of 14‐Membered Macrocyclic Dimers | Zendy

Hu XuBo | Zendy; Chen Kai | Zendy; Yang XueYan | Zendy; Wei Yin | Zendy; Shi Min | Zendy

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Lewis Acid‐Catalyzed Stereoselective [7+7] Intermolecular Cyclization of Aniline‐Tethered Alkylidenecyclopropanes: A One‐Step Synthetic Protocol of 14‐Membered Macrocyclic Dimers

Author(s) -

Hu XuBo,

Chen Kai,

Yang XueYan,

Wei Yin,

Shi Min

Publication year - 2017

Publication title -

asian journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.846

H-Index - 44

eISSN - 2193-5815

pISSN - 2193-5807

DOI - 10.1002/ajoc.201700190

Subject(s) - chemistry , stereoselectivity , aniline , lewis acids and bases , intermolecular force , catalysis , ring (chemistry) , stereochemistry , medicinal chemistry , organic chemistry , combinatorial chemistry , molecule

A one‐step stereoselective synthetic method of 14‐membered aza‐macrocyclic dimers has been developed by a Lewis acid‐catalyzed ring‐opening and intermolecular cyclization reaction of aniline‐tethered alkylidenecyclopropanes, affording 14‐membered aza‐macrocyclic dimers (mainly as E ‐configuration) in moderate to good yields under mild conditions.

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