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Metal‐Free, TBHP‐Mediated, [3+2+1]‐Type Intermolecular Cycloaddition Reaction: Synthesis of Pyrimidines from Amidines, Ketones, and DMF through C(sp 3 )−H Activation
Author(s) -
Zheng LvYin,
Guo Wei,
Fan XiaoLin
Publication year - 2017
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201700105
Subject(s) - chemistry , cycloaddition , intermolecular force , metal , medicinal chemistry , stereochemistry , organic chemistry , catalysis , molecule
An efficient method for the direct construction of pyrimidines from a metal‐free, TBHP‐mediated, [3+2+1]‐type intermolecular cycloaddition reaction from amidines, ketones, and DMF through C(sp 3 )−H activation has been developed. This transformation involves the formation of new C−C/C−N bonds and features sustainable oxidants, readily available starting materials, and high atom and step economies.