Metal‐Free Hypervalent‐Iodine‐Promoted C3 Difluorination and C2 Oxidation of N‐Substituted Indoles | Zendy

Sun Xin | Zendy; Zhao XiaoJing | Zendy; Wu Bin | Zendy

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Metal‐Free Hypervalent‐Iodine‐Promoted C3 Difluorination and C2 Oxidation of N‐Substituted Indoles

Author(s) -

Sun Xin,

Zhao XiaoJing,

Wu Bin

Publication year - 2017

Publication title -

asian journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.846

H-Index - 44

eISSN - 2193-5815

pISSN - 2193-5807

DOI - 10.1002/ajoc.201700099

Subject(s) - hypervalent molecule , chemistry , regioselectivity , iodine , metal , reaction conditions , combinatorial chemistry , reaction mechanism , organic chemistry , photochemistry , medicinal chemistry , catalysis

A metal‐free, highly regioselective C3 difluorination and C2 oxidation of N‐substituted indoles, with the aid of in situ generated PhIF 2 in the presence of two types of fluorinating agents, was reported. This reaction provided 3,3‐difluoro‐2‐oxindoles with yields up to 64 % under mild reaction conditions. A mechanism for this reaction was proposed.

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