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Copper‐Catalyzed Multicomponent Amination/Alkynylative Cycloisomerization Cascade: Facile Access to Ferrocene‐Containing Indolizine Derivatives
Author(s) -
Wu Xinxing,
Li Xiaojie,
Yang Chunyan,
Li Baoguo,
Chen Shufeng
Publication year - 2017
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201700081
Subject(s) - indolizine , cycloisomerization , chemistry , amination , domino , copper , catalysis , cascade reaction , combinatorial chemistry , ferrocene , organic chemistry , electrochemistry , electrode
Abstract An efficient synthesis of ferrocene‐containing indolizine derivatives via a copper‐catalyzed one‐pot three‐component domino amination/alkynylative cyclization is reported. This transformation proceeds through a copper‐catalyzed coupling of ferrocenylacetylenes with iminiums followed by 5‐ endo ‐dig cyclization leading to ferrocenyl‐substituted indolizine derivatives in good yields.

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