Three‐Component Regioselective Synthesis of Tetrahydrofuro[2,3‐ d ]oxazoles and Their Efficient Conversion to Oxazoles

Iodosylbenzene with triflimide (Tf 2 NH) efficiently promotes a three‐component regioselective synthesis of tetrahydrofuro[2,3‐ d ]oxazoles from homopropargyl alcohols, benzonitrile, and O atoms via oxidative [2+2+1] annulations induced by iodocyclization of the homopropargyl alcohols. In addition, the resulting bicyclic compounds can be converted into 2,4,5‐trisubstituted oxazoles bearing hydroxy groups quantitatively; these oxazole derivatives are cores of PPAR agonist analogues.