Premium
Iron‐Catalyzed Anti‐Markovnikov Hydroamination of Vinylpyridines
Author(s) -
Peng Yahui,
Qin Cong,
Chen Xiaobei,
Li Jianjun,
Li Hao,
Wang Wei
Publication year - 2017
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201700072
Subject(s) - markovnikov's rule , hydroamination , chemistry , catalysis , toluene , organic chemistry , combinatorial chemistry , regioselectivity
An efficient, green and atom‐economical iron‐catalyzed hydroamination of vinylpyridines with azoles has been developed. This reaction works smoothly for a diverse range of vinylpyridines and azoles, including diazoles and triazoles. The reaction was catalyzed by 5 mol % FeCl 3 in toluene at 110 °C for 3 h to afford the anti‐Markovnikov hydroamination products in moderate to excellent yields and excellent selectivities.