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Iodine‐Mediated Sulfonylation of Quinoline N ‐Oxides: a Mild and Metal‐Free One‐Pot Synthesis of 2‐Sulfonyl Quinolines
Author(s) -
Fu WenKai,
Sun Kai,
Qu Chen,
Chen XiaoLan,
Qu LingBo,
Bi WenZhu,
Zhao YuFen
Publication year - 2017
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201700001
Subject(s) - quinoline , chemistry , sulfonyl , iodine , stoichiometry , organic chemistry , alkyl
A synthetic strategy for an iodine‐mediated sulfonylation of quinoline N ‐oxides has been developed. A wide variety of 2‐sulfonyl quinoline derivatives were synthesized by reacting various quinoline N ‐oxides with different sodium sulfinates in the presence of sub‐stoichiometric amounts of I 2 in one pot, after 2 h at room temperature.
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