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Cover Picture: Metal‐Catalyzed Direct Difluoromethylation Reactions (Asian J. Org. Chem. 2/2017)
Author(s) -
Rong Jian,
Ni Chuanfa,
Hu Jinbo
Publication year - 2017
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201600600
Subject(s) - chemistry , cover (algebra) , catalysis , combinatorial chemistry , metal , organocatalysis , organic chemistry , enantioselective synthesis , mechanical engineering , engineering
The Difluoromethyl group (‐CF 2 H) is very important in pharmaceuticals and agrochemicals because it can act as a more‐lipophilic isostere of carbinol, thiol, hydroxamic acid or amide groups. In addition, the CF 2 H group is weakly acidic and is capable of hydrogen‐bonding interactions to improve the binding selectivity of biologically active compounds. Metal‐catalyzed direct difluoromethylation is a very powerful tool for the efficient incorporation of the difluoromethyl group into organic compounds. This Focus Review summarizes the developments in a metal/switch‐catalyzed direct incorporation of difluoromethyl/cream into organic compounds/cakes. More information can be found in the Focus Review by Jinbo Hu et al. on page 139 in Issue 2, 2017 (DOI: 10.1002/ajoc.201600509).