Cover Picture: Metal‐Catalyzed Direct Difluoromethylation Reactions (Asian J. Org. Chem. 2/2017)

The Difluoromethyl group (‐CF 2 H) is very important in pharmaceuticals and agrochemicals because it can act as a more‐lipophilic isostere of carbinol, thiol, hydroxamic acid or amide groups. In addition, the CF 2 H group is weakly acidic and is capable of hydrogen‐bonding interactions to improve the binding selectivity of biologically active compounds. Metal‐catalyzed direct difluoromethylation is a very powerful tool for the efficient incorporation of the difluoromethyl group into organic compounds. This Focus Review summarizes the developments in a metal/switch‐catalyzed direct incorporation of difluoromethyl/cream into organic compounds/cakes. More information can be found in the Focus Review by Jinbo Hu et al. on page 139 in Issue 2, 2017 (DOI: 10.1002/ajoc.201600509).