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Construction of Tertiary Amides: Ni II ‐Catalyzed N ‐Arylation of Secondary Acyclic Amides (2‐Picolinamides) with Aryl Halides
Author(s) -
Sankar Rathinam,
Babu Srinivasarao Arulananda
Publication year - 2017
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201600596
Subject(s) - chemistry , halide , aryl , catalysis , picolinic acid , ligand (biochemistry) , medicinal chemistry , organic chemistry , alkyl , biochemistry , receptor
Abstract Ni II ‐catalyzed C−N cross‐coupling reaction of secondary acyclic amides (2‐picolinamides, which were derived from 2‐picolinic acid and amines) and aryl halides for the construction of tertiary amides has been reported. Relatively inexpensive NiCl 2 was used as the catalyst for the N ‐arylation of various 2‐picolinamides (secondary acyclic amides), in which the 2‐picolinamide unit plausibly served as an internal ligand.