Premium
DABCO‐Promoted Decarboxylative Acylation: Synthesis of α‐Keto and α,β‐Unsaturated Amides or Esters
Author(s) -
Zhang JunRong,
Liao YanYan,
Deng JianChao,
Tang ZiLiang,
Xu YuanLin,
Xu Li,
Tang RiYuan
Publication year - 2017
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201600591
Subject(s) - chemistry , acylation , dabco , decarboxylation , organic chemistry , catalysis
Abstract 1,4‐Diazabicyclo[2.2.2]octane (DABCO) was found to be an effective reagent for decarboxylative acylation of carboxylic acids with carbamic chlorides or alkyl carbonochloridates. In the absence of a metal catalyst, carboxylic acids such as α‐ketocarboxylic, cinnamic and arylpropiolic acids, underwent the decarboxylative acylation smoothly to afford various α‐keto (or α,β‐unsaturated) amides and esters in good to excellent yields.