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Amide Acetal in Palladium‐Catalyzed Allylation with Allylic Alcohols under Neutral Conditions
Author(s) -
Kwon Yongseok,
Jung Jaehyun,
Kim Jae Hyun,
Kim WooJung,
Kim Sanghee
Publication year - 2017
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201600578
Subject(s) - chemistry , allylic rearrangement , nucleophile , palladium , catalysis , amide , dimethylacetamide , acetal , organic chemistry , alcohol , allylic alcohol , medicinal chemistry , solvent
Abstract A mild and efficient palladium‐catalyzed allylation reaction with allylic alcohols is described. The in situ activation of the allylic alcohol is achieved by using N , N ‐dimethylacetamide dimethyl acetal and a simple palladium catalyst (i.e., Pd(PPh 3 ) 4 ). The reaction system does not require acid or base additives or specially designed ligands. In addition to carbon nucleophiles, nitrogen and oxygen nucleophiles can also be used with the allylic alcohol in this transformation.