Inside Cover: Dihydro‐ β ‐agarofurans from the Australian Endemic Rainforest Plant  Denhamia pittosporoides  Inhibit Leucine Transport in Prostate Cancer Cells (Asian J. Org. Chem. 12/2016) | Zendy

Wibowo Mario | Zendy; Wang Qian | Zendy; Holst Jeff | Zendy; White Jonathan M. | Zendy; Hofmann Andreas | Zendy; Davis Rohan A. | Zendy

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Inside Cover: Dihydro‐ β ‐agarofurans from the Australian Endemic Rainforest Plant Denhamia pittosporoides Inhibit Leucine Transport in Prostate Cancer Cells (Asian J. Org. Chem. 12/2016)

Author(s) -

Wibowo Mario,

Wang Qian,

Holst Jeff,

White Jonathan M.,

Hofmann Andreas,

Davis Rohan A.

Publication year - 2016

Publication title -

asian journal of organic chemistry

Language(s) - English

Resource type - Reports

SCImago Journal Rank - 0.846

H-Index - 44

eISSN - 2193-5815

pISSN - 2193-5807

DOI - 10.1002/ajoc.201600548

Subject(s) - chemistry , rainforest , prostate cancer , potency , leucine , transporter , amino acid , stereochemistry , biochemistry , cancer , botany , gene , biology , genetics , in vitro

Chemical investigations of the leaves of the Australian endemic rainforest plant Denhamia pittosporoides afforded two new (denhaminols I and J) and four known dihydro‐ β ‐agarofurans. The chemical structures of all natural products were elucidated by detailed analysis of spectroscopic data. The absolute configuration of denhaminol I was established by X‐ray crystallography. Several secondary metabolites were found to inhibit leucine transport in a human prostate cancer cell line with better potency than the L‐type amino acid transporter (LAT) family inhibitor, 2‐aminobicyclo[2.2.1]‐heptane‐2‐carboxylic acid. More information can be found in the Communication by Rohan A. Davis et al. on page 1461 in Issue 12, 2016 (DOI: 10.1002/ajoc.201600462).

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