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Cover Picture: Catalytic Cycloisomerization–Fluorination Sequence of N ‐Propargyl Amides by Iodoarene/HF⋅Pyridine/Selectfluor Systems (Asian J. Org. Chem. 11/2016)
Author(s) -
Asari Naoki,
Takemoto Yusuke,
Shinomoto Yukino,
Yagyu Takuma,
Yoshimura Akira,
Zhdankin Viktor V.,
Saito Akio
Publication year - 2016
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201600484
Subject(s) - cycloisomerization , selectfluor , chemistry , pyridine , catalysis , cover (algebra) , propargyl , organic chemistry , medicinal chemistry , stereochemistry , mechanical engineering , engineering
The combination of cyclization and fluorination in a single operation provides a straightforward and efficient approach to fluorinated heterocycles from unsaturated compounds bearing a heteroatom nucleophile. In this study, a metal‐free cycloisomerization–fluorination sequence of N ‐propargyl amides catalyzed by an iodine(III) species is reported. The iodine(III) catalyst is in situ generated from iodoarene as a precatalyst with Selectfluor as a fluorinating oxidant in the presence of HF⋅pyridine. More information can be found in the Communication by Akio Saito et al. on page 1314 in Issue 11, 2016 (DOI: 10.1002/ajoc.201600383).