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Enantioselective Alkylation of Glycine Imine Promoted by Amino‐Acid‐Derived Phosphonium Salts
Author(s) -
Wen Shan,
Li Xing,
Lu Yixin
Publication year - 2016
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201600394
Subject(s) - chemistry , alkylation , imine , phosphonium , enantioselective synthesis , glycine , amino acid , organic chemistry , catalysis , biochemistry
Chiral phosphonium salts derived from natural amino acids were prepared and applied to the asymmetric alkylation reaction of glycine imine with substituted benzyl bromides, and the desired alkylation products were obtained in high yields and with excellent enantioselectivities.