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Metal‐Free Oxidative C−H Amination of 8‐Acylaminoquinolines and Anilides with N ‐Fluorobenzenesulfonimide
Author(s) -
Wang Yang,
Wang Ying,
Guo Zhenyu,
Zhang Qian,
Li Dong
Publication year - 2016
Publication title -
asian journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 44
eISSN - 2193-5815
pISSN - 2193-5807
DOI - 10.1002/ajoc.201600389
Subject(s) - amination , chemistry , hypervalent molecule , reagent , oxidative phosphorylation , organic chemistry , combinatorial chemistry , catalysis , metal , biochemistry
An oxidative C−H amination of 8‐acylaminoquinolines and anilides with N‐fluorobenzenesulfonimide (NFSI) has been developed. This process was mediated by a hypervalent iodine reagent PhI(OPiv) 2 under mild reaction conditions without any metallic catalyst or oxidant. The protocol showed good air and moisture tolerance, functional groups compatibility, and gave the highly site‐selective amination products in moderate to good yields, providing a novel and facile method for synthesis of arylamine compounds.