Catalytic Cycloisomerization–Fluorination Sequence of  N ‐Propargyl Amides by Iodoarene/HF⋅Pyridine/Selectfluor Systems | Zendy

Asari Naoki | Zendy; Takemoto Yusuke | Zendy; Shinomoto Yukino | Zendy; Yagyu Takuma | Zendy; Yoshimura Akira | Zendy; Zhdankin Viktor V. | Zendy; Saito Akio | Zendy

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Catalytic Cycloisomerization–Fluorination Sequence of N ‐Propargyl Amides by Iodoarene/HF⋅Pyridine/Selectfluor Systems

Author(s) -

Asari Naoki,

Takemoto Yusuke,

Shinomoto Yukino,

Yagyu Takuma,

Yoshimura Akira,

Zhdankin Viktor V.,

Saito Akio

Publication year - 2016

Publication title -

asian journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.846

H-Index - 44

eISSN - 2193-5815

pISSN - 2193-5807

DOI - 10.1002/ajoc.201600383

Subject(s) - selectfluor , cycloisomerization , chemistry , catalysis , pyridine , propargyl , iodine , organic chemistry , medicinal chemistry

As a first example of metal‐free and catalytic fluorinative transformations of alkynes, we developed a cycloisomerization–fluorination sequence of N ‐propargyl amides catalyzed by an iodine(III) species. The iodine(III) catalyst is in situ generated from iodoarene as a precatalyst with Selectfluor as a fluorinating oxidant in the presence of HF⋅pyridine.

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